Regulation of Iron Homeostasis Through Parkin-mediated Lactoferrin Ubiquitylation

Gholkar, A. A.; Schmollinger, S.; Velasquez, E. F.; Lo, Y.-C.; Cohn, W.; Capri, J.; Dharmarajan, H.; Deardorff, W. J.; Gao, L. W.; Abdusamad, M.; Whitelegge, J. P.; Torres, J. Z.

doi:10.1101/2020.06.04.133637

bioRxiv · 10.1101/2020.06.04.133637

Regulation of Iron Homeostasis Through Parkin-mediated Lactoferrin Ubiquitylation

Gholkar, A. A.·Schmollinger, S.·Velasquez, E. F.·Lo, Y.-C.·Cohn, W.·Capri, J.·Dharmarajan, H.·Deardorff, W. J.·Gao, L. W.·Abdusamad, M.·Whitelegge, J. P.·Torres, J. Z.

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Abstract

Somatic mutations that perturb Parkin ubiquitin ligase activity and the misregulation of iron homeostasis have both been linked to Parkinsons disease. Lactotransferrin is a member of the transferrin iron binding proteins that regulate iron homeostasis and increased levels of Lactotransferrin and its receptor have been observed in neurodegenerative disorders like Parkinsons disease. Here, we report that Parkin binds to Lactotransferrin and ubiquitylates it to regulate iron homeostasis.

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Gholkar, A. A., Schmollinger, S., Velasquez, E. F., Lo, Y.-C., Cohn, W., Capri, J., Dharmarajan, H., Deardorff, W. J., Gao, L. W., Abdusamad, M., Whitelegge, J. P., Torres, J. Z.. 2020-06-05. Regulation of Iron Homeostasis Through Parkin-mediated Lactoferrin Ubiquitylation. https://doi.org/10.1101/2020.06.04.133637

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