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bioRxiv · 10.1101/2020.06.03.131219

Discovering compounds mimicking calorie restriction using mammalian gene expression profiles

Vazquez, A.
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Abstract

Obesity is a risk factor for cardiovascular diseases, diabetes and cancer. In theory the obesity problem could be solve by the adherence to a calorie restricted diet, but that is not generally achieved in practice. An alternative is a pharmacological approach, using compounds that trigger the same metabolic changes associated with calorie restriction. Here I expand in the pharmacological direction by identifying compounds that induce liver gene signature profiles that mimic those induced by calorie restriction. Using gene expression profiles from mice and rat I identify corticosteroids, PPAR agonists and some antibacterial/antifungal as candidate compounds mimicking the response to calorie restriction in the liver gene signatures. Liver gene signature analysis can be used to identify compounds that mimic calorie restriction.

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Vazquez, A.. 2020-06-03. Discovering compounds mimicking calorie restriction using mammalian gene expression profiles. https://doi.org/10.1101/2020.06.03.131219

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