Recovery of Consciousness and Cognition after General Anesthesia in Humans

Mashour, G. A.; Palanca, B. J. A.; Basner, M.; Li, D.; Wang, W.; Blain-Moraes, S.; Lin, N.; Maier, K.; Muench, M.; Tarnal, V.; Vanini, G.; Ochroch, E. A.; Hogg, R.; Schwarz, M.; Maybrier, H.; Hardie, R.; Janke, E.; Golmirzaie, G.; Picton, P.; McKinstry-Wu, A.; Avidan, M.; Kelz, M.

doi:10.1101/2020.05.28.121269

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bioRxiv · 10.1101/2020.05.28.121269

Recovery of Consciousness and Cognition after General Anesthesia in Humans

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Abstract

Understanding how consciousness and cognitive function return after a major perturbation is important clinically and neurobiologically. To address this question, we conducted a three-center study of 30 healthy humans receiving general anesthesia at clinically relevant doses for three hours. We administered a pre- and post-anesthetic battery of neurocognitive tests, recorded continuous electroencephalography to assess cortical dynamics, and monitored sleep-wake activity before and following anesthetic exposure. We hypothesized that cognitive reconstitution would be a process that evolved over time in the following sequence: attention, complex scanning and tracking, working memory, and executive function. Contrary to our hypothesis, executive function returned first and electroencephalographic analyses revealed that frontal cortical dynamics recovered faster than posterior cortical dynamics. Furthermore, actigraphy indicated normal sleep-wake patterns in the post-anesthetic period. These recovery patterns of higher cognitive function and arousal states suggest that the healthy human brain is resilient to the effects of deep general anesthesia.

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Mashour, G. A., Palanca, B. J. A., Basner, M., Li, D., Wang, W., Blain-Moraes, S., Lin, N., Maier, K., Muench, M., Tarnal, V., Vanini, G., Ochroch, E. A., Hogg, R., Schwarz, M., Maybrier, H., Hardie, R., Janke, E., Golmirzaie, G., Picton, P., McKinstry-Wu, A., Avidan, M., Kelz, M.. 2020-05-30. Recovery of Consciousness and Cognition after General Anesthesia in Humans. https://doi.org/10.1101/2020.05.28.121269

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