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bioRxiv · 10.1101/2020.05.26.114488

Frequency-specific meso-scale structure of spontaneous oscillatory activity in the human brain

Iandolo, R.·Semprini, M.·Mantini, D.·Buccelli, S.·Sona, D.·Avanzino, L.·Chiappalone, M.
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Abstract

Recent studies provide novel insights into the meso-scale organization of the brain, highlighting the co-occurrence of different structures: classic assortative (modular), disassortative and core-periphery. However, the spectral properties of the brain meso-scale remain mostly unexplored. To fill this knowledge gap, we investigated how the meso-scale structure is organized across the frequency domain. We analyzed the resting state activity of healthy participants with source-localized high-density electroencephalography signals. Then, we inferred the community structure using weighted stochastic block-modelling to capture the landscape of meso-scale structures across the frequency domain. We found that meso-scale modalities were mixed over the frequency spectrum, with a core-periphery structure predominance. Nevertheless, we also highlighted a selective increase of disassortativity in the delta and theta bands, and of assortativity in the low gamma band (30-50 Hz). We further described other features of the meso-scale organization by identifying those brain regions which, at the same time, i) exhibited the highest degree of assortativity, disassortativity and core-peripheriness (i.e. participation), ii) were consistently assigned to the same community, irrespective from the granularity imposed by WSBM (i.e. granularity-invariance). We defined those brain areas as Participation and Granularity Invariant. In conclusion, we observed that the brain spontaneous activity shows frequency-specific meso-scale organization which may support spatially distributed and local information processing.

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Iandolo, R., Semprini, M., Mantini, D., Buccelli, S., Sona, D., Avanzino, L., Chiappalone, M.. 2020-05-26. Frequency-specific meso-scale structure of spontaneous oscillatory activity in the human brain. https://doi.org/10.1101/2020.05.26.114488

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