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bioRxiv · 10.1101/2020.05.05.078980

Validity of the Lumen(R) hand-held metabolic device to measure fuel utilization in healthy young adults

Lorenz, K. A.·Yeshurun, S.·Aziz, R.·Ortiz-Delatorre, J.·Bagley, J. R.·Mor, M.·Kern, M.
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Abstract

BackgroundMetabolic carts measure the carbon dioxide produced and oxygen consumed from the breath in order to assess metabolic fuel usage (carbohydrates vs. fats). However, these systems are expensive, time-consuming, and only available in the clinic. A small hand-held device capable of measuring metabolic fuel via CO2 from exhaled air has been developed ObjectiveTo evaluate the validity of a novel hand-held device (Lumen(R)) for measuring metabolic fuel utilization in healthy young adults MethodsMetabolic fuel usage was assessed in healthy participants (n = 33; age: 23.1 {+/-} 3.9 y) via respiratory exchange ratio (RER) values from the "gold-standard" metabolic cart as well as %CO2 from the Lumen device. Measurements were performed at rest in two conditions, fasting, and after consuming 150 grams of glucose in order to determine changes in metabolic fuel. Reduced major axis regression was performed as well as Bland-Altman plots and linear regressions to test for agreement between RER and Lumen %CO2. ResultsBoth RER and Lumen %CO2 significantly increased after glucose intake compared with fasting conditions (P < .0001). Regression analyses and Bland-Altman plots revealed an agreement between the two measurements with a systematic bias resulting from the nature of the different units. ConclusionsThis study shows the validity of Lumen(R) to estimate metabolic fuel utilization in a comparable manner with the "gold-standard" metabolic cart, providing the ability for real-time metabolic information for users under any circumstances.

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Lorenz, K. A., Yeshurun, S., Aziz, R., Ortiz-Delatorre, J., Bagley, J. R., Mor, M., Kern, M.. 2020-05-07. Validity of the Lumen(R) hand-held metabolic device to measure fuel utilization in healthy young adults. https://doi.org/10.1101/2020.05.05.078980

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