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bioRxiv · 10.1101/2020.04.13.039826

Synaptic learning rules for sequence learning

Abstract

Remembering the temporal order of a sequence of events is a task easily performed by humans in everyday life, but the underlying neuronal mechanisms are unclear. This problem is particularly intriguing as human behavior often proceeds on a time scale of seconds, which is in stark contrast to the much faster millisecond time-scale of neuronal processing in our brains. One long-held hypothesis in sequence learning suggests that a particular temporal fine-structure of neuronal activity -- termed "phase precession" -- enables the compression of slow behavioral sequences down to the fast time scale of the induction of synaptic plasticity. Using mathematical analysis and computer simulations, we find that -- for short enough synaptic learning windows -- phase precession can improve temporal-order learning tremendously and that the asymmetric part of the synaptic learning window is essential for temporal-order learning. To test these predictions, we suggest experiments that selectively alter phase precession or the learning window and evaluate memory of temporal order.

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BibTeXRIS

Reifenstein, E. T., Richard, K.. 2020-04-15. Synaptic learning rules for sequence learning. https://doi.org/10.1101/2020.04.13.039826

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