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bioRxiv · 10.1101/2020.04.08.032565

Dynamics of the cell-free DNA methylome of metastatic castration resistant prostate cancer during androgen-targeting treatment

Peter, M. R.·Bilenky, M.·Isserlin, R.·Bader, G. D.·Shen, S. Y.·De Carvalho, D. D.·Hansen, A. R.·Hu, P.·Fleshner, N. E.·Joshua, A. M.·Hirst, M.·Bapat, B.
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Abstract

AimWe examined methylation changes in cell-free DNA (cfDNA) in metastatic castration resistant prostate cancer (mCRPC) during treatment. Materials and MethodsGenome-wide methylation analysis of sequentially collected cfDNA samples derived from mCRPC patients undergoing androgen-targeting therapy was performed. ResultsAlterations in methylation states previously implicated in prostate cancer progression were observed and patients that maintained methylation changes throughout therapy tended to have a longer time to clinical progression (TTP). Importantly, we also report that markers associated with a highly aggressive form of the disease, Neuroendocrine-CRPC, were associated with a faster TTP. ConclusionOur findings highlight the potential of monitoring cfDNA methylome during therapy in mCRPC, which may serve as predictive markers of response to androgen-targeting agents.

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Peter, M. R., Bilenky, M., Isserlin, R., Bader, G. D., Shen, S. Y., De Carvalho, D. D., Hansen, A. R., Hu, P., Fleshner, N. E., Joshua, A. M., Hirst, M., Bapat, B.. 2020-04-09. Dynamics of the cell-free DNA methylome of metastatic castration resistant prostate cancer during androgen-targeting treatment. https://doi.org/10.1101/2020.04.08.032565

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