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bioRxiv · 10.1101/2020.04.07.030205

Dual mechanisms of ictal high frequency oscillations in human rhythmic onset seizures

Abstract

High frequency oscillations (HFOs) recorded from intracranial electrodes during epileptiform discharges are a proposed biomarker of epileptic brain tissue and may also be useful for seizure forecasting, with mixed results. Despite such potential for HFOs, there is limited investigation into the spatial context of HFOs and their relationship to simultaneously recorded neuronal activity. We sought to further understand the biophysical underpinnings of ictal HFOs using unit recordings in the human neocortex and mesial temporal lobe during rhythmic onset seizures. We compare features of ictal discharges in both the seizure core and penumbra (spatial seizure domains defined by multiunit activity patterns). We report differences in spectral features, unit-local field potential coupling, and information theoretic characteristics of HFOs before and after local seizure invasion. Furthermore, we tie these timing-related differences to spatial domains of seizures, showing that penumbral discharges are widely distributed and less useful for seizure localization.

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Smith, E. H., Merricks, E. M., Liou, J.-y., Casadei, C., Melloni, L., Thesen, T., Friedman, D., Doyle, W., Emerson, R. G., Goodman, R., McKhann, G. M., Sheth, S., Rolston, J. D., Schevon, C.. 2020-04-10. Dual mechanisms of ictal high frequency oscillations in human rhythmic onset seizures. https://doi.org/10.1101/2020.04.07.030205

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