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bioRxiv · 10.1101/2020.04.06.027698

Genetic variability in the expression of the SARS-CoV-2 host cell entry factors across populations

Ortiz-Fernandez, L.·Sawalha, A. H.
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Abstract

The entry of SARS-CoV-2 into host cells is dependent upon angiotensin-converting enzyme 2 (ACE2), which serves as a functional attachment receptor for the viral spike glycoprotein, and the serine protease TMPRSS2 which allows fusion of the viral and host cell membranes. We devised a quantitative measure to estimate genetic determinants of ACE2 and TMPRSS2 expression and applied this measure to >2,500 individuals. Our data show significant variability in genetic determinants of ACE2 and TMPRSS2 expression among individuals and between populations, and demonstrate a genetic predisposition for lower expression levels of both key viral entry genes in African populations. These data suggest that genetic factors might lead to lower susceptibility for SARS-CoV-2 infection in African populations and that host genetics might help explain inter-individual variability in disease susceptibility and severity of COVID-19.

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Ortiz-Fernandez, L., Sawalha, A. H.. 2020-04-14. Genetic variability in the expression of the SARS-CoV-2 host cell entry factors across populations. https://doi.org/10.1101/2020.04.06.027698

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