Alpha oscillations do not implement gain control in early visual cortex but rather gating in parieto-occipital regions

Abstract

Spatial attention provides a mechanism for respectively enhancing relevant and suppressing irrelevant information. While it is well-established that attention modulates oscillations in the alpha band, it remains unclear if alpha oscillations are involved in directly modulating the neuronal excitability associated with the allocation of spatial attention. In this study in humans, we utilized a novel broadband frequency (60 - 70 Hz) tagging paradigm to quantify neuronal excitability in relation to alpha oscillations in a spatial attention paradigm. We used magnetoencephalography to characterize ongoing brain activity as it allows for localizing the sources of both the alpha and frequency tagging responses. We found that attentional modulation of alpha power and the frequency tagging response are uncorrelated over trials. Importantly, the neuronal sources of the tagging response were localized in early visual cortex (V1) whereas the sources of the alpha activity were identified around parieto-occipital sulcus. Moreover, we found that attention did not modulate the latency of the frequency tagged responses. Our findings point to alpha band oscillations serving a downstream gating role rather than implementing gain control of excitability in early visual regions. Significance StatementBy combining magnetoencephalography and a novel broadband frequency tagging approach, we show that spatial attention differently modulates alpha oscillations and neuronal excitability. Importantly, the sources of the alpha oscillations and tagging responses were spatially distinct and the alpha power and tagging response were not related over trials. These results are inconsistent with previous ideas suggesting that alpha oscillations are involved in gain control of early sensory regions; rather alpha oscillations are involved in the allocation of neuronal resources in downstream regions.