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bioRxiv · 10.1101/2020.03.24.004085

Channel Embedding for Informative Protein Identification from Highly Multiplexed Images

Abstract

Interest is growing rapidly in using deep learning to classify biomedical images, and interpreting these deep-learned models is necessary for life-critical decisions and scientific discovery. Effective interpretation techniques accelerate biomarker discovery and provide new insights into the etiology, diagnosis, and treatment of disease. Most interpretation techniques aim to discover spatially-salient regions within images, but few techniques consider imagery with multiple channels of information. For instance, highly multiplexed tumor and tissue images have 30-100 channels and require interpretation methods that work across many channels to provide deep molecular insights. We propose a novel channel embedding method that extracts features from each channel. We then use these features to train a classifier for prediction. Using this channel embedding, we apply an interpretation method to rank the most discriminative channels. To validate our approach, we conduct an ablation study on a synthetic dataset. Moreover, we demonstrate that our method aligns with biological findings on highly multiplexed images of breast cancer cells while outperforming baseline pipelines.

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BibTeXRIS

Magid, S. A., Jang, W.-D., Schapiro, D., Wei, D., Tompkin, J., Sorger, P. K., Pfister, H.. 2020-03-25. Channel Embedding for Informative Protein Identification from Highly Multiplexed Images. https://doi.org/10.1101/2020.03.24.004085

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