Efficient inactivation of SARS-CoV-2 by WHO-recommended hand rub formulations and alcohols

Kratzel, A.; Todt, D.; V'kovski, P.; Steiner, S.; Gultom, M. L.; Thao, T. T. N.; Ebert, N.; Holwerda, M.; Steinmann, J.; Niemeyer, D.; Dijkman, R.; Kampf, G.; Drosten, C.; Steinmann, E.; Thiel, V.; Pfaender, S.

doi:10.1101/2020.03.10.986711

bioRxiv · 10.1101/2020.03.10.986711

Efficient inactivation of SARS-CoV-2 by WHO-recommended hand rub formulations and alcohols

Kratzel, A.·Todt, D.·V'kovski, P.·Steiner, S.·Gultom, M. L.·Thao, T. T. N.·Ebert, N.·Holwerda, M.·Steinmann, J.·Niemeyer, D.·Dijkman, R.·Kampf, G.·Drosten, C.·Steinmann, E.·Thiel, V.·Pfaender, S.

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Abstract

The recent emergence of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing COVID-19 is a major burden for health care systems worldwide. It is important to address if the current infection control instructions based on active ingredients are sufficient. We therefore determined the virucidal activity of two alcohol-based hand rub solutions for hand disinfection recommended by the World Health Organization (WHO), as well as commercially available alcohols. Efficient SARS-CoV-2 inactivation was demonstrated for all tested alcohol-based disinfectants. These findings show the successful inactivation of SARS-CoV-2 for the first time and provide confidence in its use for the control of COVID-19. ImportanceThe current COVID-19 outbreak puts a huge burden on the worlds health care systems. Without effective therapeutics or vaccines being available, effective hygiene measure are of utmost importance to prevent viral spreading. It is therefore crucial to evaluate current infection control strategies against SARS-CoV-2. We show the inactivation of the novel coronavirus for the first time and endorse the importance of disinfectant-based hand hygiene to reduce SARS-CoV-2 transmission.

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Kratzel, A., Todt, D., V'kovski, P., Steiner, S., Gultom, M. L., Thao, T. T. N., Ebert, N., Holwerda, M., Steinmann, J., Niemeyer, D., Dijkman, R., Kampf, G., Drosten, C., Steinmann, E., Thiel, V., Pfaender, S.. 2020-03-17. Efficient inactivation of SARS-CoV-2 by WHO-recommended hand rub formulations and alcohols. https://doi.org/10.1101/2020.03.10.986711

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