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bioRxiv · 10.1101/2020.03.10.986463

An empirical examination of sample size effects on population demographic estimates in birds using single nucleotide polymorphism (SNP) data

Abstract

Sample size is a critical aspect of study design in population genomics research, yet few empirical studies have examined the impacts of small sample sizes. We used datasets from eight diverging bird lineages to make pairwise comparisons at different levels of taxonomic divergence (populations, subspecies, and species). Our data are from loci linked to ultraconserved elements (UCEs) and our analyses used one SNP per locus. All individuals were genotyped at all loci (McLaughlin et al. 2020). We estimated population demographic parameters (effective population size, migration rate, and time since divergence) in a coalescent framework using Diffusion Approximation for Demographic Inference ({delta}a{delta}i; Gutenkunst et al. 2009), an allele frequency spectrum (AFS) method. Using divergence-with-gene-flow models optimized with full datasets, we subsampled at sequentially smaller sample sizes from full datasets of 6 - 8 diploid individuals per population (with both alleles called) down to 1:1, and then we compared estimates and their changes in accuracy. Accuracy was strongly affected by sample size, with considerable differences among estimated parameters and among lineages. Effective population size parameters ({nu}) tended to be underestimated at low sample sizes (fewer than 3 diploid individuals per population, or 6:6 haplotypes in coalescent terms). Migration (m) was fairly consistently estimated until [≤] 2 individuals per population, and no consistent trend of over- or underestimation was found in either time since divergence (T) or{Theta} (4Nref). Lineages that were taxonomically recognized above the population level (subspecies and species pairs; i.e., deeper divergences) tended to have lower variation in scaled root mean square error (SMRSE) of parameter estimation at smaller sample sizes than population-level divergences, and many parameters were estimated accurately down to 3 diploid individuals per population. Shallower divergence levels (i.e., populations) often required at least 5 individuals per population for reliable demographic inferences using this approach. Although divergence levels might be unknown at the outset of study design, our results provide a framework for planning appropriate sampling and for interpreting results if smaller sample sizes must be used.

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BibTeXRIS

McLaughlin, J. F., Winker, K.. 2020-03-12. An empirical examination of sample size effects on population demographic estimates in birds using single nucleotide polymorphism (SNP) data. https://doi.org/10.1101/2020.03.10.986463

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