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bioRxiv · 10.1101/2020.03.02.973677

Bayesian Structural Time Series for Mobile Health and Sensor Data: A Flexible Modeling Framework for Evaluating Interventions

Liu, J.·Spakowicz, D. J.·Hoyd, R.·Ash, G. I.·Lou, S.·Lee, D.·Zhang, J.·Presley, C.·Greene, A.·Papachristos, A. V.·Gerstein, M.
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Abstract

The development of mobile-health technology has the potential to revolutionize personalized medicine. Biomedical sensors (e.g. wearables) can assist with determining treatment plans for individuals, provide quantitative information to healthcare providers, and give objective measurements of health, leading to the goal of precise phenotypic correlates for genotypes. Even though treatments and interventions are becoming more specific and datasets more abundant, measuring the causal impact of health interventions requires careful considerations of complex covariate structures as well as knowledge of the temporal and spatial properties of the data. Thus, biomedical sensor data need to make use of specialized statistical models. Here, we show how the Bayesian structural time series framework, widely used in economics, can be applied to these data. We further show how this framework corrects for covariates to provide accurate assessments of interventions. Furthermore, it allows for a time-dependent confidence interval of impact, which is useful for considering individualized assessments of intervention efficacy. We provide a customized biomedical adaptor tool around a specific Google implementation of the Bayesian structural time series framework that uniformly processes, prepares, and registers diverse biomedical data. We apply the resulting software implementation to a structured set of examples in biomedicine to showcase the ability of the framework to evaluate interventions with varying levels of data richness and covariate complexity. In particular, we show how the framework is able to evaluate an exercise interventions effect on stabilizing blood glucose in a diabetes dataset. We also provide a future-anticipating illustration from a behavioral dataset showcasing how the framework integrates complex spatial covariates. Overall, we show the robustness of the Bayesian structural time series framework when applied to biomedical sensor data, highlighting its increasing value for current and future datasets.

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Liu, J., Spakowicz, D. J., Hoyd, R., Ash, G. I., Lou, S., Lee, D., Zhang, J., Presley, C., Greene, A., Papachristos, A. V., Gerstein, M.. 2020-03-04. Bayesian Structural Time Series for Mobile Health and Sensor Data: A Flexible Modeling Framework for Evaluating Interventions. https://doi.org/10.1101/2020.03.02.973677

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