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bioRxiv · 10.1101/2020.02.17.951939

Protection of Rhesus Macaque from SARS-Coronavirus challenge by recombinant adenovirus vaccine

Chen, Y.·Qin, C.·Wei, Q.·Li, R.·Gao, H.·Zhu, H.·Deng, W.·Bao, L.·Wei, T.
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Abstract

A recombinant adenovirus vaccine against the SARS Coronavirus (SARS-CoV) was constructed, which contains fragments from the S, N, and Orf8 genes. Rhesus Macaques immunized with the recombinant adenovirus generated antigen-specific humoral and cellular response. Furthermore, the vaccine provided significant protection against subsequent live SARS-CoV challenge. In contrast, three out of four monkeys immunized with placebo suffered severe alveolar damage and pulmonary destruction.

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Chen, Y., Qin, C., Wei, Q., Li, R., Gao, H., Zhu, H., Deng, W., Bao, L., Wei, T.. 2020-02-21. Protection of Rhesus Macaque from SARS-Coronavirus challenge by recombinant adenovirus vaccine. https://doi.org/10.1101/2020.02.17.951939

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