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bioRxiv · 10.1101/2020.02.14.950188

RNAAgeCalc: A multi-tissue transcriptional age calculator

Ren, X.·Kuan, P. F.
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Abstract

We introduced RNAAgeCalc, a versatile across-tissue and tissue-specific transcriptional age calculator. We utilized GTEx database to identify 1,616 common age-related genes based on meta-analysis of transcriptional age signature across multi-tissues. Additionally, tissue-specific age-related genes were obtained from differential expression analysis on individual tissues. By performing across-tissue transcriptional age prediction, we showed that our 1,616 common age-related genes outperformed other prior age related gene signatures. Furthermore, we utilized TCGA database to demonstrate that the transcriptional age acceleration computed from our within-tissue predictor was significantly correlated with mutation burden, mortality risk and cancer stage. RNAAgeCalc is available at http://www.ams.sunysb.edu/~pfkuan/softwares.html#RNAAgeCalc.

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Ren, X., Kuan, P. F.. 2020-02-15. RNAAgeCalc: A multi-tissue transcriptional age calculator. https://doi.org/10.1101/2020.02.14.950188

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