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bioRxiv · 10.1101/2020.01.02.893255

Encoding of reinforcement along the hippocampal long axis and the transition from exploration to exploitation

Abstract

When making decisions, should one exploit known good options or explore potentially better alternatives? Exploration of spatially unstructured options depends on the neocortex, striatum, and amygdala. In natural environments, however, better options often cluster together, forming structured value distributions. The hippocampus binds reward information into allocentric cognitive maps to support navigation and foraging in such spaces. Using a reinforcement learning task with a spatially structured reward function, we show that human posterior hippocampus (PH) invigorates exploration while anterior hippocampus (AH) supports the transition to exploitation. These dynamics depend on differential reinforcement representations in the PH and AH. Whereas local reward prediction error signals are early and phasic in the PH tail, global value maximum signals are delayed and sustained in the AH body. AH compresses reinforcement information across episodes, updating the location and prominence of the value maximum and displaying goal cell-like ramping activity when navigating toward it.

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Dombrovski, A. Y., Luna, B., Hallquist, M. N.. 2020-01-02. Encoding of reinforcement along the hippocampal long axis and the transition from exploration to exploitation. https://doi.org/10.1101/2020.01.02.893255

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