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bioRxiv · 10.1101/2019.12.29.890467

Genotype Effects and Gene x Environment Interactions on Inter-Individual Licking Received and Licking Provisioning in Female Rat Offspring

Lauby, S. C.·Ashbrook, D. G.·Malik, H. R.·Chatterjee, D.·Pan, P.·Fleming, A. S.·McGowan, P. O.
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Abstract

In most mammals, mothers exhibit natural variations in care that propagate between generations of female offspring. However, there is limited information on genetic variation that influences this propagation. We assessed early-life maternal care received by individual female rat offspring in relation to genetic polymorphisms linked to dopaminergic activity, maternal care provisioning, and dopaminergic activity in the maternal brain. We also conducted a systematic analysis of other genetic variants potentially related to maternal behavior in our Long-Evans rat population. We found that dopamine receptor 2 (rs107017253) variation interacted with the relationship between early-life maternal care received and dopamine levels in the nucleus accumbens which, in turn, were associated with later-life maternal care provisioning. We also discovered and validated new variants that were predicted by our systematic analysis. Our findings suggest that genetic variation influences the relationship between maternal care received and maternal care provisioning, similar to findings in human populations.

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Lauby, S. C., Ashbrook, D. G., Malik, H. R., Chatterjee, D., Pan, P., Fleming, A. S., McGowan, P. O.. 2019-12-30. Genotype Effects and Gene x Environment Interactions on Inter-Individual Licking Received and Licking Provisioning in Female Rat Offspring. https://doi.org/10.1101/2019.12.29.890467

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