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bioRxiv · 10.1101/2019.12.17.879668

Clinical correlates of sarcopenia and falls in Parkinson's disease

Lima, D. P.·de Almeida, S. B.·Bonfadini, J. d. C.·de Luna, J. R. G.·de Alencar, M. S.·Pinheiro-Neto, E. B.·Viana-Junior, A. B.·Veras, S. R. O.·Sobreira-Neto, M. A.·Roriz-Filho, J. d. S.·Braga-Neto, P.
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Abstract

BackgroundSarcopenia is a complex and multifactorial geriatric condition seen in several chronic degenerative diseases. This study aimed to screen for sarcopenia and fall risk in a sample of Parkinsons disease (PD) patients and to investigate demographic and clinical factors associated. MethodsThis is a cross-sectional study. We evaluated 218 PD patients at the Movement Disorders Clinic in Fortaleza, Brazil, and collected clinical data including experiencing falls in the six months prior to their medical visit. Probable sarcopenia diagnosis was confirmed by using a sarcopenia screening tool (SARC-F questionnaire) and the presence of low muscle strength. ResultsOne hundred and twenty-one patients (55.5%) were screened positive for sarcopenia using the SARC-F and 103 (47.4%) met the criteria for probable sarcopenia. Disease duration, modified Hoehn and Yahr stage, Schwab and England Activities of Daily Living Scale score, levodopa equivalent dose, probable sarcopenia and positive SARC-F screening were all associated with experiencing falls in the prior six months. Disease duration, lower quality of life and female gender were independently associated with sarcopenia. Experiencing falls in the prior six months was significantly more frequent among patients screened positive in the SARC-F compared to those screened negative. ConclusionsSarcopenia and PD share common pathways and may affect each others prognosis and patients quality of life. Since sarcopenia is associated with lower quality of life and increased risk of falls, active case finding, diagnosis and proper management of sarcopenia in PD patients is essential.

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Lima, D. P., de Almeida, S. B., Bonfadini, J. d. C., de Luna, J. R. G., de Alencar, M. S., Pinheiro-Neto, E. B., Viana-Junior, A. B., Veras, S. R. O., Sobreira-Neto, M. A., Roriz-Filho, J. d. S., Braga-Neto, P.. 2019-12-17. Clinical correlates of sarcopenia and falls in Parkinson's disease. https://doi.org/10.1101/2019.12.17.879668

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