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bioRxiv · 10.1101/198044

A blueprint for human whole-cell modeling

Szigeti, B.·Roth, Y. D.·Sekar, J. A. P.·Goldberg, A. P.·Pochiraju, S. C.·Karr, J. R.
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Abstract

Whole-cell models of human cells are a central goal of systems biology. Such models could help researchers understand cell biology and help physicians treat disease. Despite significant challenges, we believe that human whole-cell models are rapidly becoming feasible. To develop a plan for achieving human whole-cell models, we analyzed the existing models of individual cellular pathways, surveyed the biomodeling community, and reflected on our experience developing whole-cell models of bacteria. Based on these analyses, we propose a plan for a project, termed the Human Whole-Cell Modeling Project, to achieve human whole-cell models. The foundations of the plan include technology development, standards development, and interdisciplinary collaboration.

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Szigeti, B., Roth, Y. D., Sekar, J. A. P., Goldberg, A. P., Pochiraju, S. C., Karr, J. R.. 2017-10-03. A blueprint for human whole-cell modeling. https://doi.org/10.1101/198044

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