Quantifying Seasonal and Diel Variation in Anopheline and Culex Human Biting Rates in Southern Ecuador

Ryan, S. J.; Lippi, C. A.; Boersch-Supan, P. H.; Heydari, N.; Silva, M.; Adrian, J.; Noblecilla, L. F.; Ayala, E. B.; Encalada, M. D.; Larsen, D. A.; Krisher, J. T.; Krisher, L.; Fregosi, L.; Stewart-Ibarra, A. M.

doi:10.1101/192773

bioRxiv · 10.1101/192773

Quantifying Seasonal and Diel Variation in Anopheline and Culex Human Biting Rates in Southern Ecuador

Ryan, S. J.·Lippi, C. A.·Boersch-Supan, P. H.·Heydari, N.·Silva, M.·Adrian, J.·Noblecilla, L. F.·Ayala, E. B.·Encalada, M. D.·Larsen, D. A.·Krisher, J. T.·Krisher, L.·Fregosi, L.·Stewart-Ibarra, A. M.

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Abstract

BackgroundQuantifying mosquito biting rates for specific locations enables estimation of mosquito-borne disease risk, and can inform intervention efforts. Measuring biting itself is fraught with ethical concerns, so the landing rate of mosquitoes on humans is often used as a proxy measure. Southern coastal Ecuador was historically endemic for malaria (P. falciparum and P. vivax), although successful control efforts in the 2000s eliminated autochthonous transmission (since 2011). This study presents an analysis of data collected during the elimination period.\n\nMethodsWe examined human landing catch (HLC) data for three mosquito taxa: 2 malaria vectors, Anopheles albimanus and Anopheles punctimacula, and grouped Culex spp. These data were collected by the National Vector Control Service of the Ministry of Health over a 5-year time span (2007 - 2012) in five cities in southern coastal Ecuador, at multiple households, in all months of the year, during dusk-dawn (18:00-6:00) hours, often at both indoor and outdoor locations. Hurdle models were used to determine if biting activity was fundamentally different for the three taxa, and to identify spatial and temporal factors influencing bite rate. Due to the many different approaches to studying and quantifying bite rates in the literature, we also created a glossary of terms, to facilitate comparative studies in the future.\n\nResultsBiting trends varied significantly with species and time. All taxa exhibited exophagic feeding behavior, and outdoor locations increased both the odds and incidence of bites across taxa. An. albimanus was most frequently observed biting, with an average of 4.7 bites per hour. The highest and lowest respective months for significant biting activity were March and July for An. albimanus, July and August for An. punctimacula, and February and July for Culex spp.\n\nConclusionsFine-scale spatial and temporal differences exist in biting patterns among mosquito taxa in southern coastal Ecuador. This analysis provides detailed information for targeting vector control and household level behavioral interventions. These data were collected as part of routine vector surveillance conducted by the Ministry of Health, but such data have not been collected since. Reinstating such surveillance measures would provide important information to aid in preventing malaria re-emergence.

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Ryan, S. J., Lippi, C. A., Boersch-Supan, P. H., Heydari, N., Silva, M., Adrian, J., Noblecilla, L. F., Ayala, E. B., Encalada, M. D., Larsen, D. A., Krisher, J. T., Krisher, L., Fregosi, L., Stewart-Ibarra, A. M.. 2017-09-22. Quantifying Seasonal and Diel Variation in Anopheline and Culex Human Biting Rates in Southern Ecuador. https://doi.org/10.1101/192773

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