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bioRxiv · 10.1101/190280

k-mer Distributions of Aminoacid Sequences are Optimised Across the Proteome

Morozov, A. A.
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Abstract

k-mer based methods are widely utilized for the analysis of nucleotide sequences and were successfully applied to proteins in several works. However, the reasons for the species-specificity of aminoacid k-mer distributions are unknown. In this work I show that performance of these methods is not only due to orthology between k-mers in different proteomes, which implies the existence of some factors optimizing k-mer distributions of proteins in a species-specific manner. Whatever these factors could be, they are affecting most if not all proteins and are more pronounced in structurally organized regions.

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Morozov, A. A.. 2017-09-18. k-mer Distributions of Aminoacid Sequences are Optimised Across the Proteome. https://doi.org/10.1101/190280

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