KCC1 Activation protects Mice from the Development of Experimental Cerebral Malaria.

Hortle, E.; Brown, F.; Stephen, J.; Curtis, D.; McMorran, B.; Foote, S.; Burgio, G.

doi:10.1101/186262

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bioRxiv · 10.1101/186262

KCC1 Activation protects Mice from the Development of Experimental Cerebral Malaria.

Hortle, E.·Brown, F.·Stephen, J.·Curtis, D.·McMorran, B.·Foote, S.·Burgio, G.

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Abstract

Plasmodium falciparum malaria causes half a million deaths per year, with up to 9% of this mortality caused by cerebral malaria (CM). One of the major processes contributing to the development of CM is an excess of host inflammatory cytokines. Recently K+ signaling has emerged as an important mediator of the inflammatory response to infection; we therefore investigated whether mice carrying an ENU induced activation of the electroneutral K+ channel KCC1 had an altered response to Plasmodium berghei. Here we show that Kcc1M935K/M935K mice are protected from the development of experimental cerebral malaria, and that this protection is associated with an increased CD4+ T cells and TNF- response. This is the first description of a K+ channel affecting the development of experimental cerebral malaria.

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Hortle, E., Brown, F., Stephen, J., Curtis, D., McMorran, B., Foote, S., Burgio, G.. 2017-09-08. KCC1 Activation protects Mice from the Development of Experimental Cerebral Malaria.. https://doi.org/10.1101/186262

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