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bioRxiv · 10.1101/180729

Asymmetric MukB ATPases are regulated independently by the N- and C-terminal domains of MukF kleisin

Abstract

The Escherichia coli SMC complex, MukBEF, acts in chromosome segregation. MukBEF shares the distinctive architecture of other SMC complexes, with one prominent difference; unlike other kleisins, MukF forms dimers through its N-terminal domain. We show that a 4-helix bundle adjacent to the MukF dimerization domain interacts functionally with the MukB coiled-coiled neck adjacent to the ATPase head, forming an asymmetric tripartite complex, as in other SMC complexes. Since MukF dimerization is preserved during this interaction, MukF directs the formation of dimer of dimers MukBEF complexes, observed previously in vivo. The MukF N- and C-terminal domains stimulate ATPase independently and additively, consistent with them each targeting only one of the two MukB ATPase active sites in the asymmetric complex. We demonstrate that MukF interaction with the MukB neck turns over during cycles of ATP binding and hydrolysis in vivo and that impairment of this interaction leads to MukBEF release from chromosomes.

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Zawadzka, K., Zawadzki, P., Baker, R., Rajasekar, K., Sherratt, D. J., Arciszewska, L.. 2017-08-25. Asymmetric MukB ATPases are regulated independently by the N- and C-terminal domains of MukF kleisin. https://doi.org/10.1101/180729

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