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bioRxiv · 10.1101/172247

The Impact of Education on Myopia: A bidirectional Mendelian randomisation analysis in UK Biobank

Mountjoy, E. J.·Davies, N. M.·Plotnikov, D.·Davey Smith, G.·Rodriguez, S.·Williams, C.·Guggenheim, J. A.·Atan, D.
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Abstract

Myopia, or short-sightedness, is one of the leading causes of visual disability in the World. The prevalence of myopia has risen steadily over recent decades, reaching epidemic levels in Southeast Asia. Observational studies have reported associations between educational attainment and myopia. Whether education causes myopia, myopic children are more intelligent, or another factor, like higher socioeconomic status, causes both is unclear since observational studies are prone to confounding and randomised trials of education are unethical. Using bidirectional Mendelian Randomisation, a form of instrumental variable (IV) analysis free from confounding, we show that every additional year in education leads to an increase in myopic refractive error, but that myopia does not lead to higher educational attainment. Our results suggest that current educational methods contribute to the global burden of myopia, and argue that educational policies and practices should take account of this to reduce future visual disability in the population.

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Mountjoy, E. J., Davies, N. M., Plotnikov, D., Davey Smith, G., Rodriguez, S., Williams, C., Guggenheim, J. A., Atan, D.. 2017-08-04. The Impact of Education on Myopia: A bidirectional Mendelian randomisation analysis in UK Biobank. https://doi.org/10.1101/172247

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