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bioRxiv · 10.1101/169102

Catecholaminergic Manipulation Alters Dynamic Network Topology Across Behavioral States

Shine, J.·van den Brink, R.·Hernaus, D.·Nieuwenhuis, S.·Poldrack, R.
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Abstract

The human brain is able to flexibly adapt its information processing capacity to meet a variety of cognitive challenges. Recent evidence suggests that this flexibility is reflected in the dynamic reorganization of the functional connectome. The ascending catecholaminergic arousal systems of the brain are a plausible candidate mechanism for driving alterations in network architecture, enabling efficient deployment of cognitive resources when the environment demands them. We tested this hypothesis by analyzing both task-free and task-based fMRI data following the administration of atomoxetine, a noradrenaline reuptake inhibitor, compared to placebo, in two separate human fMRI studies. Our results demonstrate that the manipulation of central catecholamine levels leads to a reorganization of the functional connectome in a manner that is sensitive to ongoing cognitive demands.

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Shine, J., van den Brink, R., Hernaus, D., Nieuwenhuis, S., Poldrack, R.. 2017-07-27. Catecholaminergic Manipulation Alters Dynamic Network Topology Across Behavioral States. https://doi.org/10.1101/169102

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