Objective, Quantitative, Data-Driven Assessment of Chemical Probes

Antolin, A. A.; Tym, J. E.; Komianou, A.; Collins, I.; Workman, P.; Al-Lazikani, B.

doi:10.1101/168369

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bioRxiv · 10.1101/168369

Objective, Quantitative, Data-Driven Assessment of Chemical Probes

Antolin, A. A.·Tym, J. E.·Komianou, A.·Collins, I.·Workman, P.·Al-Lazikani, B.

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Abstract

Chemical probes are essential tools for understanding biological systems and for target validation, yet selecting tools for biomedical research is largely biased and subjective. Here we describe the Probe Miner: Chemical Probes Objective Assessment resource - capitalising on the plethora of public medicinal chemistry data to empower quantitative, objective, Big Data-driven assessment of chemical probes. We assess >1.8m compounds for their suitability as chemical tools against 2,220 human targets and dissect their biases and limitations.

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Antolin, A. A., Tym, J. E., Komianou, A., Collins, I., Workman, P., Al-Lazikani, B.. 2017-07-25. Objective, Quantitative, Data-Driven Assessment of Chemical Probes. https://doi.org/10.1101/168369

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