Capturing the diversity of biological tuning curves using generative adversarial networks

Abstract

Tuning curves characterizing the response selectivities of biological neurons often exhibit large degrees of irregularity and diversity across neurons. Theoretical network models that feature heterogeneous cell populations or random connectivity also give rise to diverse tuning curves. However, a general framework for fitting such models to experimentally measured tuning curves is lacking. We address this problem by proposing to view mechanistic network models as generative models whose parameters can be optimized to fit the distribution of experimentally measured tuning curves. A major obstacle for fitting such models is that their likelihood function is not explicitly available or is highly intractable to compute. Recent advances in machine learning provide ways for fitting generative models without the need to evaluate the likelihood and its gradient. Generative Adversarial Networks (GAN) provide one such framework which has been successful in traditional machine learning tasks. We apply this approach in two separate experiments, showing how GANs can be used to fit commonly used mechanistic models in theoretical neuroscience to datasets of measured tuning curves. This fitting procedure avoids the computationally expensive step of inferring latent variables, e.g., the biophysical parameters of individual cells or the particular realization of the full synaptic connectivity matrix, and directly learns model parameters which characterize the statistics of connectivity or of single-cell properties. Another strength of this approach is that it fits the entire, joint distribution of experimental tuning curves, instead of matching a few summary statistics picked a priori by the user. More generally, this framework opens the door to fitting theoretically motivated dynamical network models directly to simultaneously or non-simultaneously recorded neural responses.