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bioRxiv · 10.1101/148551

Striatal cholinergic receptor activation causes a rapid, selective, & state-dependent rise in corticostriatal β activity.

Pittman-Polletta, B. R.·Quach, A.·Mohammed, A. I.·Romano, M.·Kondabolou, K.·Kopell, N. J.·Han, X.·McCarthy, M. M.
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Abstract

Cortico-basal ganglia-thalamic (CBT) {beta} oscillations (15-30 Hz) are elevated in Parkinsons disease and correlated with movement disability. To date, no experimental paradigm outside of loss of dopamine has been able to specifically elevate {beta} oscillations in the CBT loop. Here, we show that activation of striatal cholinergic receptors selectively increased {beta} oscillations in mouse striatum and motor cortex. In individuals showing simultaneous {beta} increases in both striatum and M1, {beta} partial directed coherence (PDC) increased from striatum to M1 (but not in the reverse direction). In individuals that did not show simultaneous {beta} increases, {beta} PDC increased from M1 to striatum (but not in the reverse direction), and M1 was characterized by persistent {beta}-HFO phase-amplitude coupling. Finally, the direction of {beta} PDC distinguished between {beta} subbands. This suggests: (1) striatal cholinergic tone exerts state-dependent and frequency-selective control over CBT {beta} power and coordination; (2) ongoing rhythmic dynamics can determine whether elevated {beta} oscillations are expressed in striatum and M1; (3) altered striatal cholinergic tone differentially modulates distinct {beta} subbands.

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Pittman-Polletta, B. R., Quach, A., Mohammed, A. I., Romano, M., Kondabolou, K., Kopell, N. J., Han, X., McCarthy, M. M.. 2017-07-05. Striatal cholinergic receptor activation causes a rapid, selective, & state-dependent rise in corticostriatal β activity.. https://doi.org/10.1101/148551

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