Genetics of the Research Domain Criteria (RDoC): genome-wide association study of delay discounting

Sanchez-Roige, S.; Fontanillas, P.; Elson, S. L.; - The 23andMe Research Team,; Pandit, A.; Schmidt, E.; Forster, J.; Abecasis, G. R.; Gray, J. C.; de Wit, H.; Davis, L. K.; MacKillop, J.; Palmer, A. A.

doi:10.1101/146936

bioRxiv · 10.1101/146936

Genetics of the Research Domain Criteria (RDoC): genome-wide association study of delay discounting

Sanchez-Roige, S.·Fontanillas, P.·Elson, S. L.·- The 23andMe Research Team,·Pandit, A.·Schmidt, E.·Forster, J.·Abecasis, G. R.·Gray, J. C.·de Wit, H.·Davis, L. K.·MacKillop, J.·Palmer, A. A.

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Abstract

Delay discounting (DD), which is the tendency to discount the value of delayed versus current rewards, is elevated in a constellation of diseases and behavioral conditions. We performed a genome-wide association study of DD using 23,127 research participants of European ancestry. The most significantly associated SNP was rs6528024 (P = 2.40 x 10-8), which is located in an intron of the gene GPM6B. We also showed that 12% of the variance in DD was accounted for by genotype, and that the genetic signature of DD overlapped with attention-deficit/hyperactivity disorder, schizophrenia, major depression, smoking, personality, cognition, and body weight.

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Sanchez-Roige, S., Fontanillas, P., Elson, S. L., - The 23andMe Research Team,, Pandit, A., Schmidt, E., Forster, J., Abecasis, G. R., Gray, J. C., de Wit, H., Davis, L. K., MacKillop, J., Palmer, A. A.. 2017-06-07. Genetics of the Research Domain Criteria (RDoC): genome-wide association study of delay discounting. https://doi.org/10.1101/146936

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