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bioRxiv · 10.1101/143537

nQuire: A Statistical Framework For Ploidy Estimation Using Next Generation Sequencing

Weiss, C. L.·Pais, M.·Cano, L. M.·Kamoun, S.·Burbano, H. A.
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Abstract

SummarynQuire is a statistical framework that distinguishes between diploids, triploids and tetraploids using next generation sequencing. The command-line tool models the distribution of base frequencies at variable sites using a Gaussian Mixture Model, and uses maximum likelihood to select the most plausible ploidy model.\n\nAvailability and ImplementationThe model is implemented as a stand-alone Linux command line tool in the C programming language and is available at github under the MIT licence. Please also refer to github.com/clwgg/nQuire for usage instructions. Contact: clemens.weiss@tuebingen.mpg.de or hernan.burbano@tuebingen.mpg.de

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Weiss, C. L., Pais, M., Cano, L. M., Kamoun, S., Burbano, H. A.. 2017-05-29. nQuire: A Statistical Framework For Ploidy Estimation Using Next Generation Sequencing. https://doi.org/10.1101/143537

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