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bioRxiv · 10.1101/141523

Swapping Of Transmembrane Domains In The Epithelial Calcium Channel TRPV6

Singh, A. K.·Saotome, K.·Sobolevsky, A. I.
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Abstract

Tetrameric ion channels have either swapped or non-swapped arrangements of the S1-S4 and pore domains. Here we show that mutations in the transmembrane domain of TRPV6 can result in conversion from a domain-swapped to non-swapped fold. These results reveal structural determinants of domain swapping and raise the possibility that a single ion channel subtype can fold into either arrangement in vivo, affecting its function in normal or disease states.

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Singh, A. K., Saotome, K., Sobolevsky, A. I.. 2017-05-24. Swapping Of Transmembrane Domains In The Epithelial Calcium Channel TRPV6. https://doi.org/10.1101/141523

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