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bioRxiv · 10.1101/138099

Bifunctionality Of A Biofilm Matrix Protein Controlled By Redox State

Abstract

Biofilms are communities of microbial cells that are encapsulated within a self-produced polymeric matrix. The matrix is critical to the success of biofilms in diverse habitats, but despite this many details of the composition, structure, and function remain enigmatic. Biofilms formed by the Gram-positive bacterium Bacillus subtilis depend on the production of the secreted film-forming protein BslA. Here we show that a gradient of electron acceptor availability through the depth of the biofilm gives rise to two distinct functional roles for BslA and that these can be genetically separated through targeted amino acid substitutions. We establish that monomeric BslA is necessary and sufficient to give rise to complex biofilm architecture, while dimerization of BslA is required to render the community hydrophobic. Dimerization of BslA, mediated by disulfide bond formation, depends on two conserved cysteine residues located in the C-terminal region. Our findings demonstrate that bacteria have evolved multiple uses for limited elements in the matrix, allowing for alternative responses in a complex, changing environment.\n\nSignificanceThe biofilm matrix is a critical target in the hunt for novel strategies to destabilise or stabilise biofilms. Knowledge of the processes controlling matrix assembly is therefore an essential prerequisite to exploitation. Here we highlight that the complexity of the biofilm matrix is even higher than anticipated with one matrix component making two independent functional contributions to the community. The influence the protein exerts is dependent on the local environmental properties, providing another dimension to consider during analysis. These findings add to the evidence that bacteria can evolve multifunctional uses for the extracellular matrix components.

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BibTeXRIS

Arnaouteli, S., Ferreira, A. S., Schor, M., Morris, R. J., Bromley, K. M., Jo, J. K., Cortez, K. L., Sukhodub, T., Prescott, A. R., Dietrich, L. E. P., MacPhee, C. E., Stanley-Wall, N.. 2017-05-15. Bifunctionality Of A Biofilm Matrix Protein Controlled By Redox State. https://doi.org/10.1101/138099

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