Tissue-specific downregulation of EDTP removes polyglutamine protein aggregates and extends lifespan in Drosophila

Xiao, C.; Qiu, S.; Robertson, R. M.; Seroude, L.

doi:10.1101/130559

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bioRxiv · 10.1101/130559

Tissue-specific downregulation of EDTP removes polyglutamine protein aggregates and extends lifespan in Drosophila

Xiao, C.·Qiu, S.·Robertson, R. M.·Seroude, L.

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Abstract

Drosophila egg-derived tyrosine phosphatase (EDTP, also called JUMPY) is a lipid phosphatase essential in oogenesis and muscle function in the adult stage. Although mammalian JUMPY negatively regulates autophagy, loss-of-JUMPY causes muscle dysfunction and is associated with a rare genetic disorder called centronuclear myopathy. Here we show that tissue-specific downregulation of EDTP in Drosophila non-muscle tissues, particularly glial cells, suppresses the expression of polyglutamine (polyQ) protein aggregates in the same cells and improves survival. Additionally, tissue-specific downregulation of EDTP in glial cells or motoneurons extends lifespan. We demonstrate an approach to fine-tune the expression of a disease-associated gene EDTP for the removal of polyQ protein aggregate and lifespan extension in Drosophila.

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Xiao, C., Qiu, S., Robertson, R. M., Seroude, L.. 2017-04-25. Tissue-specific downregulation of EDTP removes polyglutamine protein aggregates and extends lifespan in Drosophila. https://doi.org/10.1101/130559

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