Components Of Alcohol Use And All-Cause Mortality

Hartz, S.; Oehlert, M.; Horton, A. C.; Grucza, R.; Fisher, S. L.; Nelson, K. G.; Sumerall, S. W.; Neal, C.; Regnier, P.; Chen, G.; Williams, A.; Bhattarai, J.; Evanoff, B.; Bierut, L. J.

doi:10.1101/129270

bioRxiv · 10.1101/129270

Components Of Alcohol Use And All-Cause Mortality

Hartz, S.·Oehlert, M.·Horton, A. C.·Grucza, R.·Fisher, S. L.·Nelson, K. G.·Sumerall, S. W.·Neal, C.·Regnier, P.·Chen, G.·Williams, A.·Bhattarai, J.·Evanoff, B.·Bierut, L. J.

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Abstract

ImportanceCurrent recommendations for low-risk drinking are based on drinking quantity: up to one drink daily for women and two drinks daily for men. Drinking frequency has not been independently examined for its contribution to mortality.\n\nObjectiveTo evaluate the impact of drinking frequency on all-cause mortality after adjusting for drinks per day and binge drinking behavior.\n\nDesignTwo independent observational studies with self-reported alcohol use and subsequent all-cause mortality: the National Health Interview Survey (NHIS), and data from Veterans Health Administration clinics (VA).\n\nSettingEpidemiological sample (NHIS) and VA outpatient database (VA Corporate Data Warehouse).\n\nParticipants208,661 individuals from the NHIS interviewed between 1997 and 2009 at the age of 30 to 70 with mortality follow-up in the last quarter of 2011; 75,515 VA outpatients born between 1948 and 1968 who completed an alcohol survey in 2008 with mortality follow-up in June 2016.\n\nExposuresQuantity of alcohol use when not binging (1-2 drinks on typical day, 3-4 drinks on typical day), frequency of non-binge drinking (never, weekly or less, 2-3 times weekly, 4 or more times weekly), and frequency of binge drinking (never, less than weekly, 1-3 times weekly, 4 or more times weekly). Covariates included age, sex, race, and comorbidity.\n\nMain Outcomes and MeasuresAll-cause mortality.\n\nResultsAfter adjusting for binge drinking behavior, survival analysis showed an increased risk for all-cause mortality among people who typically drink 1-2 drinks four or more times weekly, relative to people who typically drink 1-2 drinks at a time weekly or less (NHIS dataset HR=1.15, 95% CI 1.06-1.26; VA dataset HR=1.31, 95% CI 1.15-1.49).\n\nConclusions and RelevanceDrinking four or more times weekly increased risk of all-cause mortality, even among those who drank only 1 or 2 drinks daily. This was seen in both a large epidemiological database and a large hospital-based database, suggesting that the results can be generalized.

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Hartz, S., Oehlert, M., Horton, A. C., Grucza, R., Fisher, S. L., Nelson, K. G., Sumerall, S. W., Neal, C., Regnier, P., Chen, G., Williams, A., Bhattarai, J., Evanoff, B., Bierut, L. J.. 2017-04-21. Components Of Alcohol Use And All-Cause Mortality. https://doi.org/10.1101/129270

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