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bioRxiv · 10.1101/120667

Optimal Growth Of Microbes On Mixed Carbon Sources

Wang, X.·Tang, C.
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Abstract

A classic problem in microbiology is that bacteria display two types of growth behavior when cultured on a mixture of two carbon sources: in certain mixtures the bacteria consume the two carbon sources sequentially (diauxie) and in other mixtures the bacteria consume both sources simultaneously (co-utilization). The search for the molecular mechanism of diauxie led to the discovery of the lac operon and gene regulation in general. However, why microbes would bother to have different strategies of taking up nutrients remained a mystery. Here we show that diauxie versus co-utilization can be understood from the topological features of the metabolic network. A model of optimal allocation of protein resources to achieve maximum growth quantitatively explains why and how the cell makes the choice when facing multiple carbon sources. Our work solves a long-standing puzzle and sheds light on microbes optimal growth in different nutrient conditions.

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Wang, X., Tang, C.. 2017-03-26. Optimal Growth Of Microbes On Mixed Carbon Sources. https://doi.org/10.1101/120667

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