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bioRxiv · 10.1101/117531

HUGIn: Hi-C Unifying Genomic Interrogator

Martin, J. S.·Xu, Z.·Reiner, A. P.·Mohlke, K. L.·Sullivan, P.·Ren, B.·Hu, M.·Li, Y.
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Abstract

MotivationHigh throughput chromatin conformation capture (3C) technologies, such as Hi-C and ChlA-PET, have the potential to elucidate the functional roles of non-coding variants. However, most of published genome-wide unbiased chromatin organization studies have used cultured cell lines, limiting their generalizability.\n\nResultsWe developed a web browser, HUGIn, to visualize Hi-C data generated from 21 human primary tissues and cell liens. HUGIn enables assessment of chromatin contacts both constitutive across and specific to tissue(s) and/or cell line(s) at any genomic loci, including GWAS SNPs, eQTLs and cis-regulatory elements, facilitating the understanding of both GWAS and eQTLs results and functional genomics data.\n\nAvailabilityHUGIn is available at http://yunliweb.its.unc.edu/HUGIn.\n\nContactyunli@med.unc.edu and hum@ccf.org\n\nSupplementary information:

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Martin, J. S., Xu, Z., Reiner, A. P., Mohlke, K. L., Sullivan, P., Ren, B., Hu, M., Li, Y.. 2017-03-16. HUGIn: Hi-C Unifying Genomic Interrogator. https://doi.org/10.1101/117531

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