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bioRxiv · 10.1101/114108

Alzheimer related genes show accelerated evolution

Nitsche, A.·Reiche, K.·Ueberham, U.·Arnold, C.·Hackermueller, J.·Horn, F.·Stadler, P. F.·Arendt, T.
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Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder of unknown cause with complex genetic and environmental traits. Here, we show that gene structures of loci, that show AD-associated changes in their expression, evolve faster than the genome at large. This phylogenetic trait of AD suggests a critical pathogenetic role of recent adaptive evolution of human brain and might have far reaching consequences with respect to the appropriateness of model systems and the development of disease-modifying strategies.

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Nitsche, A., Reiche, K., Ueberham, U., Arnold, C., Hackermueller, J., Horn, F., Stadler, P. F., Arendt, T.. 2017-03-07. Alzheimer related genes show accelerated evolution. https://doi.org/10.1101/114108

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