Functional Connectivity Between Somatosensory and Motor Brain Areas Predicts Individual Differences in Motor Learning by Observing

Abstract

Action observation can facilitate the acquisition of novel motor skills, however, there is considerable individual variability in the extent to which observation promotes motor learning. Here we tested the hypothesis that individual differences in brain function or structure can predict subsequent observation-related gains in motor learning. Subjects underwent an anatomical MRI scan and resting-state fMRI scans to assess pre-observation grey matter volume and pre-observation resting-state functional connectivity (FC), respectively. On the following day, subjects observed a video of a tutor adapting her reaches to a novel force field. After observation, subjects performed reaches in a force field as a behavioral assessment of gains in motor learning resulting from observation. We found that individual differences in resting-state FC, but not grey matter volume, predicted post-observation gains in motor learning. Pre-observation resting-state FC between left S1 and bilateral PMd, M1, S1 and left SPL was positively correlated with behavioral measures of post-observation motor learning. Sensory-motor resting-state FC can thus predict the extent to which observation will promote subsequent motor learning.\n\nNew & NoteworthyWe show that individual differences in pre-observation brain function can predict subsequent observation-related gains in motor learning. Pre-observation resting-state functional connectivity within a sensory-motor network may be used as a biomarker for the extent to which observation promotes motor learning. This kind of information may be useful if observation is to be used as a way to boost neuroplasticity and sensory motor recovery for patients undergoing rehabilitation for diseases that impair movement such as stroke.