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bioRxiv · 10.1101/085506

Predicting brain-age from multimodal imaging data captures cognitive impairment

Abstract

The disparity between the chronological age of an individual and their brain-age measured based on biological information has the potential to offer clinically-relevant biomarkers of neurological syndromes that emerge late in the lifespan. While prior brain-age prediction studies have relied exclusively on either structural or functional brain data, here we investigate how multimodal brainimaging data improves age prediction. Using cortical anatomy and whole-brain functional connectivity on a large adult lifespan sample (N = 2354, age 19-82), we found that multimodal data improves brain-based age prediction, resulting in a mean absolute prediction error of 4.29 years. Furthermore, we found that the discrepancy between predicted age and chronological age captures cognitive impairment. Importantly, the brain-age measure was robust to confounding effects: head motion did not drive brain-based age prediction and our models generalized reasonably to an independent dataset acquired at a different site (N = 475). Generalization performance was increased by training models on a larger and more heterogeneous dataset. The robustness of multimodal brain-age prediction to confounds, generalizability across sites, and sensitivity to clinically-relevant impairments, suggests promising future application to the early prediction of neurocognitive disorders.\n\nHighlightsO_LIBrain-based age prediction is improved with multimodal neuroimaging data.\nC_LIO_LIParticipants with cognitive impairment show increased brain aging.\nC_LIO_LIAge prediction models are robust to motion and generalize to independent datasets from other sites.\nC_LI

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BibTeXRIS

Liem, F., Varoquaux, G., Kynast, J., Beyer, F., Kharabian Masouleh, S., Huntenburg, J. M., Lampe, L., Rahim, M., Abraham, A., Craddock, R. C., Riedel-Heller, S., Luck, T., Loeffler, M., Schroeter, M. L., Witte, A. V., Villringer, A., Margulies, D. S.. 2016-11-07. Predicting brain-age from multimodal imaging data captures cognitive impairment. https://doi.org/10.1101/085506

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