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bioRxiv · 10.1101/069120

Exaggerated CpH Methylation in the Autism-Affected Brain

Shannon E Ellis·Simone Gupta·Anna Moes·Andrew B West·Dan E Arking
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Abstract

The etiology of autism, a complex neurodevelopmental disorder, remains largely unexplained. Here, we explore the role of CpG and CpH (H=A, C, or T) methylation within autism-affected cortical brain tissue. While no individual site of methylation was significantly associated with autism after multi-test correction, methylated CpH di-nucleotides were markedly enriched in autism-affected brains (~2-fold enrichment at p <0.05 cut-off, p=0.002). These results further implicate epigenetic alterations in pathobiological mechanisms that underlie autism.

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Shannon E Ellis, Simone Gupta, Anna Moes, Andrew B West, Dan E Arking. 2016-08-11. Exaggerated CpH Methylation in the Autism-Affected Brain. https://doi.org/10.1101/069120

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