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bioRxiv · 10.1101/068585

Oxytocin enhances intrinsic corticostriatal functional connectivity in women

Richard Alexander Ingmar Bethlehem·Michael V. Lombardo·Meng-Chuan Lai·Bonnie Auyeung·Sarah Crockford·Julia Deakin·Sentil Soubramanian·Akeem Sule·Prantik Kundu·Valerie Voon·Simon Baron-Cohen
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Abstract

BackgroundOxytocin may influence various human behaviors and the connectivity across subcortical and cortical networks. Previous oxytocin studies are male-biased and often constrained by task-based inferences. Here we investigate the impact of oxytocin on resting state connectivity between subcortical and cortical networks women.\n\nMethodsWe collected resting state fMRI data on 26 typically-developing women following intranasal oxytocin administration using a double-blind placebo-controlled crossover design. Independent components analysis (ICA) was applied to examine connectivity between networks. An independent analysis of oxytocin receptor (OXTR) gene expression in human subcortical and cortical areas was carried out to determine plausibility of direct oxytocin effects on OXTR.\n\nResultsIn women, OXTR was highly expressed in striatal and other subcortical regions, but showed modest expression in cortical areas. Oxytocin increased connectivity between corticostriatal circuitry typically involved in reward, emotion, social-communication, language, and pain processing. This effect was 1.39 standard deviations above the null effect of no difference between oxytocin and placebo. This oxytocin-related effect on corticostriatal connectivity covaried with autistic traits, such that oxytocin-related increase in connectivity was stronger in individuals with higher autistic traits.\n\nDiscussionOxytocin strengthens corticostriatal connectivity in women, particularly with cortical networks that are involved in social-communicative, motivational, and affective processes. This effect may be important for future work on neurological and psychiatric conditions (e.g., autism, chronic pain), particularly through highlighting how oxytocin may operate differently for subsets of individuals.\n\nSignificance statementThis is the first study to examine how oxytocin affects corticostriatal connectivity in humans, and specifically in women. This is important given oxytocin could impact neural circuitry differently in males and females. Here, we show that oxytocin increases connectivity between corticostriatal circuitry involved in a number of social-communicative, motivational, and affective processes that are implicated in certain neuropsychiatric conditions (e.g., autism). This effect is bolstered by independent evidence that oxytocin receptor gene expression is high in striatal regions and modest in cortical areas. These results may have potential implications for personalized treatment, as oxytocin-related effects on connectivity may vary substantially between individuals.

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Richard Alexander Ingmar Bethlehem, Michael V. Lombardo, Meng-Chuan Lai, Bonnie Auyeung, Sarah Crockford, Julia Deakin, Sentil Soubramanian, Akeem Sule, Prantik Kundu, Valerie Voon, Simon Baron-Cohen. 2016-08-09. Oxytocin enhances intrinsic corticostriatal functional connectivity in women. https://doi.org/10.1101/068585

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