microRNA-mRNA interaction identification in Wilms tumor using principalcomponent analysis based unsupervised feature extraction

Y-h. Taguchi

doi:10.1101/059295

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bioRxiv · 10.1101/059295

microRNA-mRNA interaction identification in Wilms tumor using principalcomponent analysis based unsupervised feature extraction

Y-h. Taguchi

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Abstract

Wilms tumor is one of lethal child renal cancers, for which no known disease causing mechanisms exist. In this paper, we tried to identify possible disease causing microRNA(miRNA)-mRNA pairs (interactions) by analyzing (partially matched) miRNA/mRNA gene expression profiles with the recently proposed principal component analysis based unsupervised feature extraction. It successfully identified multiple miRNA-mRNA pairs whose biological natures are convincing. Correlation coefficients between miRNA and mRNA expression in matched parts of profiles turned out to be significantly negative. Constructed miRNA-mRNA network will be a key to understand Wilms tumor causing mechanisms.

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Y-h. Taguchi. 2016-06-16. microRNA-mRNA interaction identification in Wilms tumor using principalcomponent analysis based unsupervised feature extraction. https://doi.org/10.1101/059295

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