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bioRxiv · 10.1101/056705

Fast and Robust Segmentation of Copy Number Profiles Using Multi-Scale Edge Detection

Ivo W Kwee·Andrea Rinaldi·Cassio Polpo de Campos·Francesco Bertoni
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Abstract

Raw copy number data is highly dimensional, noisy and can suffer from so-called genomic wave artifacts. We introduce a novel method based on multi-scale edge detection in derivative space. By using derivatives, the algorithm was very fast and robust against genomic waves. Our method compared very well to existing state-of-the-art segmentation methods and importantly outperformed these if noise and wave artifacts were well present.

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Ivo W Kwee, Andrea Rinaldi, Cassio Polpo de Campos, Francesco Bertoni. 2016-06-02. Fast and Robust Segmentation of Copy Number Profiles Using Multi-Scale Edge Detection. https://doi.org/10.1101/056705

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