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bioRxiv · 10.1101/050310

C19ORF66 is an Interferon-Stimulated Gene (ISG) which Inhibits Human Immunodeficiency Virus-1

Weidong Xiong·Deisy Contreras·Joseph Ignatius Irudayam·Ayub Ali·Otto O Yang·Vaithilingaraja Arumugaswami
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Abstract

Innate immunity is the first line of defense against invading microbes1. The type I interferon (IFN) pathway plays a key role in controlling Human Immunodeficiency Virus type 1 (HIV-1) replication2,3. We identified an IFN- stimulated gene C19ORF66 that we term Suppressor of Viral Activity (SVA). Full length SVA-1 protein inhibits HIV-1 by blocking virion production. SVA splice variants truncated at the C-terminus and/or disrupted at the nuclear export signal (NES) lose antiviral activity and localize to nucleus, while full length SVA-1 co-localizes with HIV-1 p24 protein in the cytoplasmic compartment of infected cells. SVA-1 is structurally and functionally conserved across species, including mouse and chimpanzee. We provide the first description of the effector function of the gene SVA/C190RF66 as an innate immune factor with anti-HIV-1 activity.

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Weidong Xiong, Deisy Contreras, Joseph Ignatius Irudayam, Ayub Ali, Otto O Yang, Vaithilingaraja Arumugaswami. 2016-04-26. C19ORF66 is an Interferon-Stimulated Gene (ISG) which Inhibits Human Immunodeficiency Virus-1. https://doi.org/10.1101/050310

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