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bioRxiv · 10.1101/023226

A spatio-temporal model for spontaneous thrombus formation in cerebral aneurysms

Orestis Malaspinas·Alexis Turjman·Daniel Ribeiro de Sousa·Guillermo Garcia-Cardena·Martine Raes·Phuc-Thien Thomas Nguyen·Yue Zhang·Guy Courbebaisse·Christophe Lelubre·Karim Zouaoui Boudjeltia·Bastien Chopard
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Abstract

We propose a new numerical model to describe thrombus formation in cerebral aneurysms. This model combines CFD simulations with a set of bio-mechanical processes identified as being the most important to describe the phenomena at a large space and time scales. The hypotheses of the model are based on in vitro experiments and clinical observations. We document that we can reproduce very well the shape and volume of patient specific thrombus segmented in giant aneurysms.

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Orestis Malaspinas, Alexis Turjman, Daniel Ribeiro de Sousa, Guillermo Garcia-Cardena, Martine Raes, Phuc-Thien Thomas Nguyen, Yue Zhang, Guy Courbebaisse, Christophe Lelubre, Karim Zouaoui Boudjeltia, Bastien Chopard. 2015-07-27. A spatio-temporal model for spontaneous thrombus formation in cerebral aneurysms. https://doi.org/10.1101/023226

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