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bioRxiv · 10.1101/019000

Reconstructing A/B compartments as revealed by Hi-C using long-range correlations in epigenetic data

Jean-Philippe Fortin·Kasper D Hansen
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Abstract

Analysis of Hi-C data has shown that the genome can be divided into two compartments called A/B compartments. These compartments are cell-type specific and are associated with open and closed chromatin. We show that A/B compartments can be reliably estimated using epigenetic data from several different platforms, the Illumina 450k DNA methylation microarray, DNase hypersensitivity sequencing, single-cell ATAC sequencing and single-cell whole-genome bisulfite sequencing. We do this by exploiting the fact that the structure of long range correlations differs between open and closed compartments. This work makes A/B compartments readily available in a wide variety of cell types, including many human cancers.

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Jean-Philippe Fortin, Kasper D Hansen. 2015-05-06. Reconstructing A/B compartments as revealed by Hi-C using long-range correlations in epigenetic data. https://doi.org/10.1101/019000

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