TY - RPRT TI - Cryo-electron microscopy ensemble optimization using individual particles and physical constraints AU - Sanchez, D. S. AU - Thiede, E. H. AU - Lederman, R. AU - Cossio, P. PY - 2025 DO - 10.64898/2025.12.02.691891 UR - https://www.biorxiv.org/content/10.64898/2025.12.02.691891v1 ID - 10.64898/2025.12.02.691891 ER -