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Zoofaghari, M.

Publications and source records attributed to Zoofaghari, M..

2 recordsLinked to original sources

Semantic-Aware Energy-Efficient Operation inSmart Capsule Endoscopy

Goal-oriented semantic communication has recently emerged in wireless sensor-actuator networks, emphasizing the meaning and relevance of information over raw data delivery, thereby enabling resource-efficient telecommunication. This paradigm offers significant benefits for intra-body or implantable sensor-actuator networks, including dramatic reductions in bandwidth requirements, latency, and power consumption. In this paper, we address a patch-based energy-efficient anomaly detection method for smart capsule endoscopy. We propose a deep learningbased algorithm that employs the similarity between features extracted from measured images and a reference (normal) image as the detection metric. The algorithm is evaluated using a clinical dataset of capsule-captured images, combined with a simulated intra-body channel model. The results demonstrate that even with only 60% of the transmission power (relative to a standard link design for QPSK modulation) and 65% of the light intensity, the probability of anomaly detection remains above 85%, and it gradually improves as power and illumination levels increase. This improvement translates into a potential battery life extension of over 43%. The findings highlight the potential of semanticaware, energy-efficient intra-body devices for more sustainable and effective medical interventions.

bioinformatics↗

Empirical Model of Focused Ultrasound-mediated Treatment for Chemotherapy Delivery

Focused ultrasound (FUS) has emerged as a transformative technique for enhancing drug delivery to brain tumors by temporarily and locally disrupting the blood-brain barrier (BBB). Despite significant progress in both preclinical and clinical research, a major challenge remains: the absence of a model that connects the properties of drug particles and FUS sonication parameters to therapeutic effectiveness. In this study, we introduce a novel empirical model that integrates key factors, including drug pharmacodynamics, microbubble kinetics for BBB disruption, intra-brain ultrasound signal propagation, and skull thickness variations. The model defines a new sonication parameter that encapsulates ultrasound signal characteristics and predicts the concentration of therapeutic agents internalized or bound to DNA with an accuracy exceeding 82%. By employing data from previous preclinical studies, this model facilitates the development of precise sonication protocols tailored for clinical applications. These advancements represent a significant step toward personalized FUS-mediated treatments, bridging the gap between experimental research and patient-centered therapies.

cancer biology↗