Biology subjects

Zhang, L. W.

Publications and source records attributed to Zhang, L. W..

2 recordsLinked to original sources

bioRxiv2017

Element-Free Multiscale Modeling Of Large Deformation Behavior Of Red Blood Cell Membrane With Malaria Infection

In normal physiological and healthy conditions, red blood cells (RBCs) deform readily as they pass through the microcapillaries and the spleen. In this paper, we examine the effects of Plasmodium falciparum infection and maturation on the large deformation behavior of malaria-infected red blood cells (iRBCs) by means of a three-dimensional (3D) multiscale meshfree method. We numerically simulated the optical tweezers experiment and observed the force-displacement response of the iRBC membrane as malaria infection progresses. Our simulation results agree well with experimental data and confirm that the deformability of malaria-infected cells decreases significantly as malaria infection progresses.

biophysics↗

bioRxiv2017

Does Temperature Change Worsen Or Mitigate The Effect Of Malaria Infection On Erythrocyte Deformability?

INTRODUCTION INTRODUCTION METHODS RESULTS AND DISCUSSION REFERENCES This paper attempts to investigate whether temperature change worsen or mitigate the effect of Plasmodium falciparum (P. falciparum) infection and maturation on the deformability of malaria-infected red blood cells (iRBCs) or erythrocytes. P. falciparum infection is the most lethal malaria parasitic infection affecting humans [1]. Upon infection, the merozoites enter the bloodstream and develop through the ring (Pf-rRBC), trophozoite (Pf-tRBC) and schizont (Pf-tRBC) stages, which is usually accompanied by significant changes in body temperature. Hence, this study aims to draw a connection between temperature change and erythrocyte deformability upon malaria infection. ...

biophysics↗